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14.
J Am Acad Dermatol ; 51(5 Suppl): S166-8, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15577761

RESUMO

Extraskeletal osteosarcoma represents approximately 1% of soft tissue sarcomas and approximately 4% of all osteosarcomas. It is therefore much rarer than osteosarcoma arising primarily in bone. Skin as a primary site has seldom been reported. This report describes an extraskeletal osteosarcoma of the skin under a previously electrodessicated actinic keratosis.


Assuntos
Dessecação/métodos , Ceratose/terapia , Osteossarcoma/patologia , Neoplasias Cutâneas/patologia , Idoso , Idoso de 80 Anos ou mais , Neoplasias Faciais/patologia , Neoplasias Faciais/cirurgia , Feminino , Humanos , Ceratose/patologia , Osteossarcoma/cirurgia , Prognóstico , Neoplasias Cutâneas/cirurgia
15.
J Eur Acad Dermatol Venereol ; 18(2): 199-200, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15009305

RESUMO

Necrobiosis lipoidica (NL) is a disease of collagen. Squamous cell carcinomas developing in areas of chronic ulceration and scarring have been well documented in a variety of skin diseases but rarely in areas of necrobiosis lipoidica. The case history of a 76-year-old female is presented, whose squamous cell carcinoma appeared 30 years after the diagnosis of necrobiosis lipoidica. The clinical and histopathological picture is described, stressing the importance of the unusual association of the two pathologies in the prognostic.


Assuntos
Carcinoma de Células Escamosas/complicações , Necrobiose Lipoídica/complicações , Neoplasias Cutâneas/complicações , Idoso , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Neoplasias Cutâneas/patologia
19.
Rheumatology (Oxford) ; 42(9): 1089-92, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12730526

RESUMO

OBJECTIVE: To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis. METHODS: Seventy-four patients with psoriatic arthritis and 95 patients with psoriasis vulgaris were included in this study. Polymorphic genes and microsatellite markers centromeric (C1_2_5) and telomeric (C1_4_4, OTF3, HCR and the corneodesmosin gene) to HLA-C were studied in an association analysis. Typing was also performed on a control population of 104 matched donors. RESULTS: The allele Cw*0602 was associated both with psoriasis [49 vs 21%, Pc<0.0003; odds ratio (OR)=3.6, aetiological factor (AF)=0.72] and with psoriatic arthritis (62 vs 21%, Pc<0.000001; OR=6.1, AF=0.83). In psoriatic patients a susceptibility region telomeric to HLA-C that includes C1_4_4 (56 vs 22%, Pc<0.0002; OR=4.39, AF=0.77), OTF3 (85 vs 60%, Pc<0.0002; OR=3.7, AF=0.73) and HCR (63 vs 26%, Pc<0.00001; OR=3.8, AF=0.74) was observed. In psoriatic arthritis patients the susceptibility region was delimited by HLA-C and C1_4_4 (384 allele, 56 vs 22%, Pc<0.0002; OR=4.37, AF=0.77). CONCLUSIONS: Comparing the susceptibility regions associated with the two diseases, an overlapping interval of 100 kb between HLA-C and OTF3, which might contain the psoriasis gene, can be defined.


Assuntos
Predisposição Genética para Doença , Antígenos HLA-C/genética , Psoríase/genética , Adulto , Artrite Psoriásica/genética , Mapeamento Cromossômico , Genótipo , Humanos , Repetições de Microssatélites/genética , Pessoa de Meia-Idade , Polimorfismo Genético/genética , Telômero/genética
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